(生命科学引论)Towards_the_Complex_Simplicity.ppt

Towards the Complex Simplicity – Omics, Math and Evolution Biology used to be elegant and simple One gene/one enzyme The Ultimate Simplicity - Double Helix lac Operon – the Classical Elegance The Holy Code Engineering Biology The Magical Cycle It Smells! Omics and the resulting complexity ~ a quarter of genes are still uncharacterized even in yeast S.cerevisiae, the best studied organism The human genome is pervasively transcribed The trans-cis binding differs significantly human and mouse ~2/3 yeast genes can be deleted without significant consequence ~7% of genes with increased expression are also required for optimal growth in the conditions The Mediator complex Guilt by association Math – a solution!? The function of each promoter was dertermined A simple formula predicts PE quite well The E.coli metabolic network Comparison of E.coli growth rate between in silico prediction and adaptive evolution on glucose Evolution, evolution, and evolution… “Nothing in biology makes sense except in the light of evolution” To be simple, or to be complex For a single generation, in a given environment, most of genes are not necessary Important knowledge was discovered earlier The value of the increased detecting power??? Where are we? Synthetic Biology Thank you! Flux balance analysis: S . v = 0; ai = vi = bi Linear programming to find the optimal solution (Ibarra et. al., 2002) Molecular Biology Undertand genes Understand processes Part IV Dobzhansky (1900 – 1975) Uneven environment gain lose benefit risk save energy new niches disfunction energy-wasting Growth rate (He and Zhang, 2009) * 贺雄雷 进化基因组学实验室 中山大学生命科学学院 Biology used to be elegant and simple; Omics and the resulting complexity; Math – the ultimate solution!? Evolution, evolution, and evolution… Where are we? Gregor Mendel (1822-1884) 9:3:3:1 Part I Beadle and Tatum at 1958 Neurospora crassa as the model organism Watson and Crick Jacob at 1965 Their work was initially considered unworthy of publication, and so