原创力文档Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme：（发现deoxyvasicinone衍生品作为NEDD8-activating酶的抑制剂）.pdfVIP
- 1、本文档共6页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme：（发现deoxyvasicinone衍生品作为NEDD8-activating酶的抑制剂）
Methods 71 (2015) 71–76
Contents lists available at ScienceDirect
Methods
journal homepage: www.else /locate/ymeth
Discovery of deoxyvasicinone derivatives as inhibitors
of NEDD8-activating enzyme
Hai-Jing Zhong a, Ka-Ho Leung b, Sheng Lin b, Daniel Shiu-Hin Chan b, Quan-Bin Han c,
Sharon Lai-Fung Chan d, Dik-Lung Ma b,⇑, Chung-Hang Leung a,⇑
a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
b Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong
c School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong
d Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
a r t i c l e i n f o a b s t r a c t
Article history: NEDD8-activating enzyme (NAE) controls the specific degradation of proteins regulated by cullin-RING
Received 31 May 2014 ubiquitin E3 ligases, and has been considered as an attractive molecular target for the development of
Revised 16 August 2014 drugs against cancer. A pharmacophore model constructed from a training set of deoxyvasicinone deriv-
Accepted 22 August 2014
atives was used to screen 376 compounds from an analogue database. From the initial screening, the
Available online 4 September 2014
valine-linked deoxyvasicinone derivative 9 and the N-isopropyl-linked deoxyvasicinone derivative 10
您可能关注的文档
- Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking：（发现fragment-based BRD4 bromodomain抑制剂的高通量对接）.pdf
- discovery of highly reactive peptide tag by elisa-type screening for specific cysteine conjugation：（发现高活性肽标签elisa-type筛查特定的半胱氨酸接合）.pdf
- discovery of highly conserved unique peanut and tree nut peptides by lc–msms for multi-allergen detection：（发现树高度保守的独特的花生和坚果肽信用证）.pdf
- discovery of host-targeted covalent inhibitors of dengue virus：（登革热病毒的发现host-targeted共价抑制剂）.pdf
- discovery of diverse and functional antibodies from large human repertoire antibody libraries：（人类发现的多样化和功能抗体从大型曲目抗体库）.pdf
- discovery of discriminatory quality control markers for chinese herbal medicines and related processed products by combination of chromatographic analysis and chemometrics methods radix scutellariae a：（发现歧视中国中药质量控制指标和相关加工产品的组合色谱分析和化学计量学方法黄芩）.pdf
- discovery of furan carboxylate derivatives as novel inhibitors of atp-citrate lyase via virtual high-throughput screening：（发现呋喃羧酸盐衍生物新型抑制剂的atp柠檬酸裂解酶通过虚拟大规模筛选）.pdf
- discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under dmso-perturbed assay conditions：（透明质酸酶抑制剂的发现来自天然产物及其dmso-perturbed试验条件下的机械特性）.pdf
- discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood：（发现成人海马神经发生基于有效刺激器支架在龙的血液）.pdf
- discovery of indazole aldosterone synthase (cyp11b2) inhibitors as potential treatments for hypertension：（发现吲唑醛固酮合酶抑制剂(cyp11b2)作为潜在的治疗高血压）.pdf
文档评论（0）