原创力文档discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragons blood：（发现成人海马神经发生基于有效刺激器支架在龙的血液）.pdfVIP
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discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragons blood：（发现成人海马神经发生基于有效刺激器支架在龙的血液）
European Journal of Medicinal Chemistry 136 (2017) 382e392
Contents lists available at ScienceDirect
European Journal of Medicinal Chemistry
journal homepage: http://www.elsevier .com/locate/ejmech
Research paper
Discovery of efficient stimulators for adult hippocampal neurogenesis
based on scaffolds in dragons blood
a, * a, 1 a, 1 a b c
Jian-Hua Liang , Liang Yang , Si Wu , Si-Si Liu , Mark Cushman , Jing Tian ,
Nuo-Min Li a, Qing-Hu Yang a, He-Ao Zhang a, Yun-Jie Qiu a, Lin Xiang a, Cong-Xuan Ma a,
Xue-Meng Li a, Hong Qing a, **
a School of Life Science, Beijing Institute of Technology, Beijing 100081, China
b Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University
47907 USA
c Biomedical School, Beijing City University, Beijing 100094, China
a r t i c l e i n f o a b s t r a c t
Article history: Reduction of hippocampal neurogenesis caused by aging and neurological disorders would impair neural
Received 3 February 2017 0
circuits and result in memory loss. A new lead compound (N-trans-3 ,4-methylenedioxystilben-4-yl
Received in revised form acetamide 27) has been discovered to efficiently stimulate adult rats neurogenesis. In-depth struc-
8 May 2017
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