原创力文档discovery of three toxin peptides with kv1.3 channel and il-2 cytokine-inhibiting activities from non-buthidae scorpions, chaerilus tricostatus and chaerilus tryznai：（发现三种毒素多肽kv1.3通道和2 cytokine-inhibiting活动non-buthidae蝎子,chaerilus tricostatu）.pdfVIP
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discovery of three toxin peptides with kv1.3 channel and il-2 cytokine-inhibiting activities from non-buthidae scorpions, chaerilus tricostatus and chaerilus tryznai：（发现三种毒素多肽kv1.3通道和2 cytokine-inhibiting活动non-buthidae蝎子,chaerilus tricostatu）
Peptides 91 (2017) 13–19
Contents lists available at ScienceDirect
Peptides
j o u r na l h o me p a g e : w w w. elsev /locate/pept ides
Discovery of three toxin peptides with Kv1.3 channel and IL-2
cytokine-inhibiting activities from Non-Buthidae scorpions, Chaerilus
tricostatus and Chaerilus tryznai
Li Ding a,b,1, Jing Chen d,1, Jinbo Hao c,1, Jiahui Zhang a , Xuejun Huang a , Fangfang Hu a ,
Zheng Wu a , Yaru Liu a , Wenxin Li d , Zhijian Cao d , Yingliang Wu d , Jian Li a , Shan Li a,b ,
Hongyan Liu a,b , Wenlong Wu a,b , Zongyun Chen a,∗
a Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Hubei,
China
b Department of Clinical Laboratory, Dongfeng Hospital, Hubei University of Medicine, Hubei, China
c Department of Clinical Laboratory, Shiyan Occupational Disease Hospital, Hubei, China
d State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Hubei, China
a r t i c l e i n f o a b s t r a c t
Article history: Non-Buthidae venomous scorpions are huge natural sources of toxin peptides; however, only a few
Received 24 November 2016 studies have been done to understand their toxin peptides. Herein, we describe three new potential
Received in revised form 6 March 2017 immunomodulating toxin peptides, Ctri18, Ctry68 and Ctry2908, from two non-Buthidae scorpions,
Accepted 8 March 2017 Chaerilus tricostatus and Chaerilus tryznai. Sequence alignment analyses showed that Ctri18, Ctry68 and
Avai
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