原创力文档discovery of two p-superfamily conotoxins, lt9a and lt9b, with different modifications on voltage-sensitive sodium channels：（发现两个p-superfamily个lt9a lt9b,不同的修改电压特异性钠离子通道）.pdfVIP
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discovery of two p-superfamily conotoxins, lt9a and lt9b, with different modifications on voltage-sensitive sodium channels：（发现两个p-superfamily个lt9a lt9b,不同的修改电压特异性钠离子通道）
Toxicon 134 (2017) 6e13
Contents lists available at ScienceDirect
Toxicon
journal homepage: /l ocate/toxicon
Discovery of two P-superfamily conotoxins, lt9a and lt9b, with
different modifications on voltage-sensitive sodium channels
a, b, *, 1 b, 1 b c b
Lei Wang , Junliang Liu , Zhenghua Ren , Yu Chen , Anlong Xu
a Department of Pharmaceutical Engineering, College of Materials and Energy, College of Marine Science, South China Agricultural University, Guangzhou,
510642, PR China
b State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, National Engineering Center of South China
Sea for Marine Biotechnology, Department of Biochemistry, College of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, PR China
c MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, PR China
a r t i c l e i n f o a b s t r a c t
Article history: In this work, two P-superfamily conotoxins, lt9a and lt9b, were purified and characterized from the crude
Received 9 November 2016 venom of Conus litteratus. The amino acid sequences of lt9a and lt9b were determined by the Edman
Received in revised form degradation method. It has been suggested that both lt9a and lt9b are produced from the precursor
15 May 2017
encoded by
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