主动脉夹层动脉瘤与主动脉真性动脉瘤的单核苷酸多态性研究 PPTPPT.ppt

主动脉夹层动脉瘤与主动脉真性动脉瘤的单核苷酸多态性研究 Analysis of Candidate Genes by DNA Sequencing The α1 Chain of Type III Collagen Fibulin-2 Matrix Metallopeptidase 2 Tissue Inhibitor of Metallopeptidase 1 and 2 Cholesteryl Ester Transfer Protein Genetic Association Studies Using Known Polymorphisms in Candidate Genes Group I: Genes of the ECM—Structure and Remodeling of the Aorta Group II: Genes of the Cardiovascular System Group III: Genes of the Immune System Group IV: Genes of Signaling Pathways Group I: Genes of the ECM—Structure and Remodeling of the Aorta α1 Chain of Type III Collagen Fibrillin 1 Elastin ATP-binding Cassette Transporter, Subfamily C (CFTR/MRP), Member 6 Fibulin-5 Family of Matrix Metallopeptidases Tissue Inhibitor of Metallopeptidase 1, 2, and 3 Serine Peptidase Inhibitor, Clade A, Member 1 Serine Peptidase Inhibitor, Clade E, Member 1 Secreted Phosphoprotein 1 Xylosyltransferase 1 Cystatin C Group III: Genes of the Immune System Human Leukocyte Antigen Locus Chemokine (C-C motif) Receptor 5 Interleukin 1α, Interleukin 1β, and Interleukin 1 Receptor Antagonist Interleukin 6 (interferon β2) Interleukin 10 Phospholipase A2, Group VII Tumor Necrosis Factor Peroxisome Proliferator-Activated Receptor Gamma C-reactive Protein Heme Oxygenase (decycling) 1 Group IV: Genes of Signaling Pathways Transforming Growth Factor β1 and Transforming Growth Factor β1-Receptor Transforming Growth Factor β2-Receptor A Dutch study investigated nine different SNPs with two large case-control sets, and two of the SNPs (rs1036095 and rs4522809) showed an association with AAA in both case-control sets Transforming Growth Factor β3 Latent TGF-β Binding Proteins 1, 3, and 4 Several SNPs (nt –4234AG, 10384 GA, 21011AT, 25859CT and 32603CG) in the LTBP4 gene showed an association with AAA growth rates. Estrogen Receptors 1 and 2 and Progesterone Receptor Genome-Wide Association Studies A SNP (rs763518) located on chromosome 3p12.3, a region near contactin-3