抗菌药(英文课件)Antimicrobials.ppt

★ ★ ★ ★ ★ Amikacin (Amikin)/ Gentamicin/ Neomycin / Netromycin Aminoglycosides Amikacin (Amikin)/ Gentamicin/ Neomycin / Netromycin Bactericidal for numerous G(+) G(-) bacteria Not active in 1) oxygen-poor environment 2) low PH ? ineffective to anaerobes and abscesses Usually with β-Lactam antibiotics to GNB Synergy with PCNs to streptococcal, enterococcal endocarditis Interfering with protein synthesis during aerobic metabolism. Good potensy: concentration-dependent killing effect and time-dependent PAE on G(+) and G(-) organisms Potency depend on 1) susceptibility to ami