抗生素耐药 Resistance to antibiotics.pptVIP

Newer b-lactams aztreonam (monobactam) gram- specific resistant to b-lactamase Carbapenems: imipenem, meropenem broad spectrum (gram+,gram-) resistant to b-lactamase penetrates CSF imipenem a substrate for dehydropeptidase I in kidney, meropenem is not Brenner b-lactamase inhibitors b-lactamase inhibitors Clavulanic acid (suicide inhibitor for most lactamases) little antibiotic action on its own combine with amoxicillin to get Augmentin (oral activity) combine with ticarcillin to get Timentin Sulbactam (similar inhibitor) combine with ampicillin to get Unasyn (given iv or im) Activity of