抗生素英文课件精品Antibiotics(70p).pptVIP

Development of Drug Resistance intrinsic chromosomal mutations - low probability acquired transfer of extra chromosomal DNA from a resistant species to a sensitive one Plasmids Transposons Plasmids resistance factors or R factors transfered by conjugation, transformation or transduction Transposons sequences that can move from plasmid chromosome plasmid plasmid Clinical Trials patient - has a diagnosed infection - two possibilities: a) the new drug is the drug of choice by testing b) the patient has not responded to other drugs and the new drug is testing well in the lab s