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教学课件课件PPT医学培训课件教育资源教材讲义
Antimicrobials;Antimicrobial Agents;;Historical Perspective of Antibiotics;Antimicrobial Agents;Antimicrobial Agents;Antimicrobial Agents;Your Basic Bacteria;Antimicrobial Drugs Modes of Action;Types of Antimicrobial Resistance;Mechanisms of Resistance;
Efflux mechanisms
Acquisition of an inner membrane protein which actively pumps the antibiotic out of the cell.
E. coli acquires resistance to tetracyclines
Alternative pathway
Bacteria acquire a gene to code an alternative penicillin binding protein which is not inhibited.
Alteration of the target site
Point mutations, insertions or delet
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