抗生素作用的病理生理学Hunting intracellular bacteria with antibiotics.pptVIP

Karmanshah, Iran, 24 May 2011 1st International and 12th Iranian Congress of Microbiology Intracellular SCVs and antibiotics … its hard to exceed 2 log drop… Perhaps due to membrane-detabilization effect … Domenech et al. Biochim Biophys Acta. 2009 1788:1832-1840 Baudoux et al. ICAAC 2009 [C1-1354] Nguyen et al., Antimicrobial Agents and Chemotherapy (2009) 53:1434–1442 Will this be successful ? * Hunting intracellular bacteria with antibiotics Paul M. Tulkens, MD, PhD Cellular and Molecular Pharmacology Unit Centre for Clinical PharmacyLouvain Drug Research Institute Catholic University