抗生素英文课件精品——Discovery of Antimicrobial Drugs.pptVIP

Game plan; - 1928: Fleming discovered penicillin, produced by Penicillium ;Where to antimicrobials come from?;Broad spectrum- affect a broad range of gram-positive and gram-negative bacteria Narrow spectrum- affects a narrow range of bacteria ;This bacterium is lysing because an antibiotic disrupted its cell wall. Why doesn’t the antibiotic lyse human cells?;The Action of Antimicrobial Drugs;Case study in narrow spectrum antibiotics: Penicillin;Figure 20.7;Figure 20.21;- A variety of mutations can lead to antibiotic resistance - Misuse of antibiotics selects for resistance mutants. Misuse in