抗真菌药在宿主细胞肺内药物分布与药效动力学(英文课件)Intrapulmonary drug distribution pharmacodynamic interactions of antifungal drugs with host cells.pptVIP

Intrapulmonary drug distribution pharmacodynamic interactions of antifungal drugs with host cells;Outline;Impaired by neutropenia, glucocorticoids, metabolic abnormalities, concomitant infections;;Progressive thrombosis- inflammation-necrosis impair drug activity in invasive aspergillosis;;Invasive pulmonary aspergillosis in neutropenic mice is associated with rapid down-regulation of multiple genes involved in angioneogenesis;In vivo assessment of the anti-angiogenic effects of Aspergillus infection ;Pathological features affecting drug delivery depend on host immunosuppression;Effect of amp