门诊病人抗生素应用(英文课件)Antibiotics in Outpatients.ppt

Pharmacokinetics Well absorbed from GI tract Presence of food increases bioavailability Cranberry juice and other urinary acidifiers may have enhancing action Eliminated in urine-40% unchanged Excreted in breast milk. Do not use in mothers with infants less than one month old Oxazolidinone (Linezolid) Totally synthetic antibiotics No preexisting resistance to bacteria Unique mechanism of action: -it inhibits assembly of bacterial ribosomes No other antibiotic inhibits this process, so there is no cross-resistance Spectrum of Activity All major pathogens gram + bacteria are sens