【抗生素精品课件】Introduction for Antibiotics教学资料讲义教学资料讲义.pptVIP

Fluoroquinolones Activity: MSSA, some enterococcus, most GNB (salmonella shigella) mycobacterium, clamydia, mycoplasma, legionella, dipheria, pertusis 3rd-generation have the effect for streptococcus, anaerobes Ineffective: MRSA Fluoroquinolones Special consideration: One step mutation results in resistance Cross resistance is a common phenomenon Ciprofloxacin is not effective for streptococcus in vivo Significant hepatotoxicity: trovafloxacin, grepafloxacin Significant photosensitivity: sparfloxacin, clinafloxacin Significant cardiac adverse effect: grepafloxacin (QTc) Significant CNS exci