(精选)Benefits of Tight Blood Pressure Control in Diabetic patients with ...教学课件.pptVIP

Benefits of Tight Blood Pressure Control in Diabetic patients with Hypertension;;; After median 8.5 years post-trial follow-up Aggregate Endpoint 1997 2007 Any diabetes related endpoint RRR: 12% 9% P: 0.029 0.040 Microvascular disease RRR: 25% 24% P: 0.0099 0.001 Myocardial infarction RRR: 16% 15% P: 0.052 0.014 All-cause mortality RRR: 6% 13% P: 0.44 0.007;The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. N Engl J Med 2005;353:2643-2653;;;;;;;Possible role of suboptimal BP lowering;Influence of previous history of diabetes and delayed start of antihypertensive treatment;Factorial design of the study and impossibility to control for the effects of background interventions;Use of older less efficacious antihypertensive agents with adverse effects on glucose homeostasis;Role of a shorter median time of randomized interventions in HDS;Small differences in BP between tight and less tight BP control;Absence of BP legacy or only a time-to-effect relationship between BP control and CV outcome?;;;;;;Conclusion;