(精选)Clinical Management of Hypertensive Heart Disease教学课件.pptVIP

 Clinical Management of Hypertensive Heart Disease:Preventing Heart Failure;Prevalence of Heart Failure Increases With Age*;Adapted from Dzau V, et al. Am Heart J. 1991;2(4 pt 1):1244-1263.; 1 2 4 6 8 10;STAGE A At high risk for HF but without structural heart disease or symptoms of HF.;JNC 7: The Hypertension Guidelines;For persons over age 50, SBP is more important than DBP as CVD risk factor Starting at 115/75 mm Hg, CVD risk doubles with each increment of 20/10 mm Hg throughout the BP range Persons who are normotensive at age 55 have a 90% lifetime risk for developing hypertension Those with SBP 120-139 mm Hg or DBP 80-89 mm Hg require health-promoting lifestyle modifications to prevent CVD and should be considered prehypertensive;New Features and Key Messages (cont’d);Treatment of Hypertension;The Pyramid of HF and Potential Impact of a Range of Preventive and Treatment Strategies in Lowering Age-Specific Mortality;UKPDS?Hypertension Study:Benefits of 144/82 vs 154/87;Minority Populations;1. Yancy CW. J Card Fail. 2000;6:183-186. 2. American Heart Association. Heart Disease and Stroke Statistics—2006 Update. Dallas, TX: American Heart Association; 2006.;HF in African Americans: Overview;New Directions;TROPHY Results: Trends in SBP;Julius S, et al. N Engl J Med. 2006;354:1685-1697.;*P.0001 for all doses vs placebo. ?P.05 for 600 mg compared to 150 mg. Oh BH, et al. J Am Coll Cardiol. 2007;49:1157-1163. ;Adapted from Dzau V, et al. Am Heart J. 1991;2(4 pt 1):1244-1263.