(精选)Antibiotiká a chemoterapeutiká教学课件.pptVIP

Antibiotics and chemotherapeutics definition mechanism of action type of action toxicity and undesirable actions types of antibiotics,rational therapy ANTIBIOTICS (ATB) Selectively inhibit or kill microbes in concentrations that are not toxic for macroorganism not like desinfections and antiseptics, ATB can be used inside human body Antibiotics (ATB), antimicrobial (ATM) agents are also chemoterapeutics with antimicrobial activiry that have - source in the nature - been produced artifitially ATB according to their source: Producers can be: 1.actitnomycetes - aminoglycosides,tetracyclines, macrolides 2.other bacteria (mostly Bacillus sp.) - bacitracin, polymyxin 3.microscopic fungi (penicilium, aspergilum) - penicilíny ATB can be derived also form plants - fytoncides - from annimal tissues – ecmolins ATB according to the aim group: 1.antibacterial, antibiotics in proper sense -mostly used common 2.antimycotics -against molds and yeast 3.antiprotozoal -against eucaryotic worms, protozoa 4.antiviral -certain antiviral chemotherapeutics Bakteriostasis - situation when ATB inhibit multiplication, division of bacterial cell - bacteria are not killed Natural dieing of living form of bacteria is not influenced Baktericidia - killing of bacteria