(精选)Pneumococcal Pneumonia教学课件.pptVIP

Pneumococcal Pneumonia;Symptoms signs of pneumococcal pneumonia;Progression of pneumococcal pneumonia;Progression of pneumococcal pneumonia;Seasonal incidence of pneumonia caused by S. pneumoniae;Envelope Structure of Streptococcus pneumoniae;Polysaccharide Capsule;Therapy and prevention of S. pneumoniae infections ;Oswald Avery studies Streptococcus pneumoniae at Rockefeller University;Virulent (Smooth) and Avirulent (Rough) Pneumococci;The sugar coated microbe Pneumococcal capsular polysaccharide prevents phagocytosis;The transforming principleDNA for capsule biosynthesis;Bacterial genomes, multi-locus sequence typing (MLST) and genome sequencingtools to unravel the epidemiology of bacterial diseases;Bacterial genome sequencingsingle nucleotide polymorphisms (SNPs) in 616 US 3,805 Thai S. pneumoniae isolates and their β-lactam resistance phenotypes;Bacterial genome sequencingrecombination events in 173 isolates of post-PCV7 vaccine escape mutants detect serotype switches and changes in antibiotic resistance;Uses of bacterial genome sequencingDNA sequencing is cheap, analysis and long term data storage are expensive ;Epidemiology of bacterial disease: S. pneumoniaedrivers: disease susceptibility, mortality, immunity, single (variable) virulence trait, transformation recombination to generate capsule diversity;Vaccines against bacterial disease: S. pneumoniaedrivers: vaccine serotypes, immunity, transformation recombination to generate new (capsule) serotypes;Epidemiology of bacterial disease: C. diphtheriaedrivers: disease susceptibility, mortality, immunity, toxin=virulence, toxoid=immunity, monomorphic clone;Transposons;Bacterial conjugation- Josh Lederberg;Lysogenic or Lytic Bacteriophage Infections - Lwoff;Bacteriophage transduction - Norton Zinder;Assembly of bacteriophage lambda and related phages;Rules of thumb for bacterial pathogens;Bacterial Pathogen Rule # 1;Where does bacterial adherence and infection occur?;Listeria attachment to epithelia