(精编)【甲流H1N1精品课件】 Pandemic Influenza A (H1N1) Virology Update.pptVIP

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2018-03-21 发布于天津
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(精编)【甲流H1N1精品课件】 Pandemic Influenza A (H1N1) Virology Update.ppt

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A/Auckland/1/2009 A/South Carolina/10/2009 A/Mexico/10/2009 A/England/195/2009 A/New York/18/2009 A/California/4/2009 A/Texas/5/2009 California/7/2009 A/Nonthaburi/102/2009 A/Narita/1/2009 A/Delaware/3/2009 A/Texas/15/2009 ANTIGENIC MAPPING (CDC, 54 antigens; 16 sera) HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (CDC) Vaccines and Related Biological Products Advisory Committee MeetingJuly 23, 2009Pandemic Influenza A (H1N1)Virology Update Nancy Cox, PhDAlexander Klimov, PhDInfluenza DivisionNational Center for Immunizations and Respiratory DiseasesCenters for Disease Control and Prevention Cases (n) First US Case April 15 RT-PCR kits to US labs 4/29 – 5/3 Kits to 233 US and 386 International labs by 6/12 Vaccine candidates shipped to manufactures BEGINNING OF THE 2009 H1N1 PANDEMIC Garten, et al. Science Express 2009 HOST AND LINEAGE ORIGINS FOR THE GENE SEGMENTS OF THE 2009 A(H1N1) VIRUS 1930 Slide courtesy of Dr. Amy Vincent, NADC, USDA REASSORTANT EVENTS AMONG SWINE INFLUENZA VIRUSES (SIV)IN NORTH AMERICA HA Number of Nucleotide Differences (%) HA Number of Amino Acid Differences (%) NA Number of Nucleotide Differences (%) NA Number of Amino Acid Differences (%) A/New Jersey/8/1976 vs A/California/7/2009 (H1N1) 184 (11%) 44 (8%) 282 (20%) 82 (18%) A/Victoria/3/1975 vs A/Brisbane/10/2007 (H3N2) 185 (11%) 57 (10%) 120 (9%) 47 (10%) GENETIC DISTANCE BETWEEN A/NEW JERSEY/8/1976 AND A/TEXAS/05/2009COMPARING WITH H3N2 VIRUSES HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (CDC) HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (NIMR) HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (NIID) North America Asia and Oceania Europe Central and South America TOTAL 861 39 complete genomes sequenced COUNTRIES FOR WHICH SEQUENCING OR ANTIGENIC DATA ARE AVAILABLE Isolates tested (n) Resistant isolates % Resistance US Isolates 305 305 100 Foreign Isolates 78 78 100 Global Isolates 383 383 100 RESISTANCE OF PANDEMIC INFLUENZA H1N1v VIRUSES TOADA