(精编)【医学课件大全】Antiathrosclerotic drugs (68p)教学课件.pptVIP

乙酰CoA 乙酰乙酰CoA HMG-CoA MVA 鲨烯 HMG-CoA还原酶 胆固醇 STATINS 【 Statins 】 ① Improve the function of vascular endothelium ②↓proliferation and transfer of VSMCs ③↓formation of foam cells ④↓CRP,↓inflammation response ⑤↓Platelet aggregation and thrombosis ⑥ Stabilize atheromatous plaque Non lipidemic-modulating action  Pharmacokinetics Clinical uses 1. Ⅱa、Ⅱb、III type hyperlipoproteinemia 2. Restenosis after percutaneous transluminal coronary angioplasty 3. Prevention of acute cardiocerebrovascular attack WOSCOPS (West of Scotland Coronary Prevention Study )： Pravastatin(普伐他