(精编)Aim 3 Overview教学课件.pptVIP

Assessing Surrogacy in CKD*;Concept of Surrogate Endpoint;Difficult to Evaluate ESRD in Trials of Early CKD;Past Problems with Surrogate Endpoints;Statistical Approaches to Validating Proteinuria (UP) as Surrogate Endpoint;Association of Baseline Albuminuria with progression in RENAAL*; Early Decline in UP Predicts Better Renal Outcome;Limits of Individual Level Association (Fundamental Limitation of Causal Inference);Implicit Causal Model of Individual Association Approach ;Implicit Causal Model of Individual Association Approach ;Prentice Criterion (1989);Variations on Prentice Criteri