(精编)Antibiotic and latex allergy教学课件.pptVIP

Strained state of beta lactam ring means it readily reacts with nucleophilic groups on carrier proteins Heterogenous IgE responses seen in beta lactam allergy Pencillin - opening of the beta lactam ring and acylation of lysine residues in host proteins forming penicilloyl derminant. About 950 of penicillin molecules bind in this way and it is known as the MAJOR DERMINANT. The remaining conjugates are termed minor but they too are capable of illiciting IgE reponses Heterogenous IgE seen- some very specific to methylene groups within side chains – others to whole side chain. IN one individ