(精编)Blood-Clotting教学课件.pptVIP

Gihan Gawish.Dr Protein C is a protease that is switched on by the action of thrombin. Thus, thrombin has a dual function: it catalyzes the formation of fibrin and it initiates the deactivation of the clotting cascade. Fibrinolysis Fibrinolysis is the process wherein a fibrin clot is broken down Plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other proteases or by the kidney and liver. Plasmin is produced in an inactive form, plasminogen, in the liver. Coagulation factors and related substances I fibrinogen Forms