(精编)Choosing Antibiotics教学课件.pptVIP

Boyer E and Shannon M. N Engl J Med 2005;352:1112-1120 Spectrum of Clinical Findings Linezolid resistance Rare but has been reported with S. aureus and Enterococcus species Linezolid- pneumonia “Intrapulmonary pharmacokinetics” Require vanco trough ≥ 20 to achieve appropriate alveolar levels? In 2 RCTs (2001 and 2003) compared vanco v. linezolid for pneumonia and demonstrated no difference in outcomes (aztreonam for GNR coverage) Controversial subset analysis suggested superiority of linezolid for S. aureus pneumonia Case 3 52 M with HCV cirrhosis admitted with large volume hematemesis Hi