(精编)DIABETES INSIPIDUS教学课件.pptVIP

Osmolar Clearance vs Free Water Clearance Solute H20 urine Osmolar Clearance (Cosm) = Uosm x V -------------- Posm Uosm = 120 Posm = 326 Vol = 8.8L Cosm = 120 x 8.8 326 Cosm = 3.23L Urine vol =8.8L 3.3L (Osm) 5.5L (H20) Conclusion Polyuria is secondary to water diuresis Polyuria secondary to water diuresis Nephrogenic DI (? hypercalcemia) vs Central DI (? metastasis) Trial of DESMOPRESSIN (0.2mcg 1/2tab BID) Effect on urine volume and osmolality After the trial of Desmopressin Urine Volume 100% 8.8L ? 4.6L Urine Osmolality 100% 120 ? 423 Conclusion : CENTRA