(精编)Introduction to Antibacterial Therapy教学课件.pptVIP

Time over MIC Should exceed MIC for at least 50% of dose interval Higher doses may allow adequate time over MIC For most beta lactams, optimal time over MIC can be achieved by continuous infusion (except unstable drugs such as imipenem, ampicillin) Higher Serum/tissue levels are associated with faster killing Aminoglycosides Peak/MIC ratio of 10-12 optimal Achieved by “Once Daily Dosing” PAE helps Fluoroquinolones 10-12 ratio achieved for enteric GNR PAE helps not achieved for Pseudomonas nor Streptococcus pneumoniae AUC/MIC = AUIC For Streptococcus pneumoniae, FQ should have AUIC