液相色谱-串联质谱法测定食品用纸容器中全氟辛酸.PDFVIP

※分析检测 食品科学 2012, Vol.33, No.22 207 - 1,2 2 3 2 1,* 张 岩 ，庞 坤 ，吕 品 ，李 挥 ，卢晓宇 (1.北京出入境检验检疫局，北京 100026 ；2.河北省食品质量监督检验研究院，河北 石家庄 050091 ； 3.河北医科大学，河北 石家庄 050017) 摘 要：建立高效液相色谱- 串联质谱结合加速溶剂萃取测定食品用纸容器中全氟辛酸的方法。样品用甲醇作为 溶剂进行快速溶剂萃取。萃取液经C18 固相萃取柱富集净化后，以C18柱为分离柱，以甲醇、水为流动相，梯度洗 脱，电喷雾负离子模式下多反应监测模式检测。全氟辛酸在0.5～50ng/mL范围内线性良好(R2=0.9993) ，回收率为 90.2%～103.3%，相对标准偏差为2.74%～6.03%，检出限为0.1μg/kg(RSN=3) 。该方法操作简便，灵敏度高，适用于 食品用纸容器中全氟辛酸及其盐类残留分析。 高效液相色谱- 串联质谱；全氟辛酸；食品用纸容器；加速溶剂萃取 Determination of Perfl uorooctanoic Acid (PFOA) in Paper Food Containers by High Performance Liquid Chromatography-Tandem Mass Spectrometry 1,2 2 3 2 1,* ZHANG Yan ，PANG Kun ，LÜ Pin ，LI Hui ，LU Xiao-yu (1. Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China； 2. Hebei Institute of Food Quality Supervision Inspection and Research, Shijiazhuang 050091, China ； 3. Hebei Medical University, Shijiazhuang 050017, China) Abstract ：High performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) with accelerated solvent extraction (ASE) was used to establish a method for quantitative detection of perfl uorooctanoic acid (PFOA) in paper food containers. Samples were extracted by ASE method with methanol. The resulting extract was cleaned up using a C18 solid phase extraction (SPE) column, and separate on a chromatographic C18 column using methanol and deionized water as mobile phases by gradient elution. Instrumental analysi