高血压病患者vWF及胰岛素抵抗与中医证型的关系_张雪梅.pdf

# 200# 辽宁中医杂志 2010年第 37 卷第 2期 vWF , , , , , , ( 上海中医药大学附属岳阳中西医结合医院, 上海 200437) : 目的: 探讨高血压病患者血管性血友病因子( vWF) 及胰岛素抵抗( IR) 与中医证型之间的关系方 : 将 124例高血压患者进行中医辨证分型, 测定 BM I血压空腹血糖空腹胰岛素血浆 vWF, 同时计算 IR 的程度, IR 采用 HOMA- IR, 并对 vWF 及 IR进行相关分析结果: 患者空腹胰岛素水平在各证型之间存在显著差异, 肝火亢盛组显著高 于阴虚阳亢组及痰湿壅盛组 (P 01 01); 肝火亢盛组 IR 显著高于痰湿壅盛组 (P 0101), 各组间 IR 水平为肝火亢盛 组 阴阳两虚组 阴虚阳亢组 痰湿壅盛组; 高血压病患者阴阳两虚组血浆 vW F 水平显著高于其他 3 组, 且 vWF与年 龄呈正相关 (R = 01 308, P 01 01)年龄每上升 1岁, vWF 水平上升 01 978M u/mL结论: 高龄高血压患者可能存在血管 内皮损伤, 更易血栓形成; 肝火亢盛组 IR 最高, 提示有明显的糖代谢紊乱 : 高血压; 胰岛素抵抗; vWF; 中医证型 : R2 9. 44 1 : B : 1000- 1719( 2010) 02- 0200- 03 TheRelationship AmongPlasma vWF Insulin Resistance and TCM Syndromes inHypertension ZHAN G X ue-m e,i F U D e-yu, WAN G Shi-hong, H E Shu-y in, Z U L iang-hua, XIN X iao-y i, ZHA O Yan-gong ( Yueyang H o p ital Aff iliated to Shanghai Univer ity of TCM , Shanghai 200437, China) Abstract:Obj ective: To d iscuss the relationship am ong plasma vWF, insu lin resistance and TCM syndrom es in hypertension. M ethod : One hundred and wt enty-four patientsw ith hypertens ionw ere selected and differentiatedTCM syndrom es. BM I, BP, fast- ing b lood-glucose, fasting insu lin and plasm a vWF w ere detected. IR is evaluated by fasting blood-glucose value and fasting insu lin level. The correlation of vW F w ith IR is analyzed. R e ult : There exists sign ificant d ifference am ong the patientsc fasting insu lin level in different TCM syndrom es. Com pared w ith hyperactivity of yang due to yin deficiency type and the stagnation of ph legm- dam pness type, fasting insulin level in hyperactivity of liver-yang type is sign ificantly higher(P 0101). IR in hyperactivity of liv- er-yang type is s ignificantly h igher than that in stagnat