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Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis.Am J Med.2005,118:11-8. * 5 RCTs, 896 patients Subglottic secretion drainage reduced the incidence of VAP by nearly half (risk ratio [RR] = 0.51; 95% confidence interval [CI]: 0.37 to 0.71) primarily by reducing early-onset pneumonia Subglottic secretion drainage shortened the duration of mechanical ventilation by 2 days (95% CI: 1.7 to 2.3 days) Shortened the length of stay in the intensive care unit by 3 days (95% CI: 2.1 to 3.9 days) delayed the onset of pneumonia by 6.8 days (95% CI: 5.5