Antihypertensive Drugs-Cardiovascular Pharmacology抗高血压，心血管药理学.pptVIP

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2018-04-01 发布于江西
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Antihypertensive Drugs-Cardiovascular Pharmacology抗高血压，心血管药理学.ppt

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Antihypertensive Drugs-Cardiovascular Pharmacology抗高血压，心血管药理学

Cardiovascular Pharmacology Antihypertensive Drugs As blood volume returning to the heart increases, preload increases and there is enhanced filling with ventricular dilation. α2-Adrenergic Agonist ? clonidine ? major action is in the brain (tends to overrideaction in the periphery) – decrease sympathetic tone – sedative effect at higher doses Clonidine Approved uses: – Treatment of hypertension – For severe pain in cancer patients THANKS! Calcium Channel Blockers Dihydropyridines Amlodipine Felodipine Nimodipine Isradipine Nicardipine Nifedipine Non-Dihydropyridines Bepridil Diltiazem Verapamil Angiotensin Converting Enzyme Inhibitors (ACEI)Benazepril Captopril Enalapril Fosinopril Quinapril Ramipril Angiotensin Receptor Blocker Saralasin Losartan Irbesartin Systolic hypertension Classification of Arterial Hypertension Systolic and Diastolic hypertension Miscellaneous Renal?Disease Endocrine Disease Neurogenic Disease Unknown Etiology Etiology Renal?Disease ◆ Renovascular stenosis or renal infarction ◆ Polycystic kidney disease ◆ Acute and chronic glomerulonephritis ◆ Chronic pyelonephritis ◆ Renin-producing tumors ◆ Other severe renal diseases Endocrine?Diesease ◆ Adrenocortical hyperactivity (Cushing‘s disease, primary hyperaldosteronism) ◆ Oral contraceptives ◆ Pheochromcytoma ◆ Acromegaly ◆ Myxedema Neurogenic Disease ◆ Psychogenic ◆ Polyneuritis ◆ Elevated intracranial pressure ◆ Familial dysautonomia Miscellaneous ◆ Increased intravascular volume ◆ Polyarteritis nodosa ◆ Hypercalcemia ◆ Aortic coarctation Unknown Etiology ◆ Toxemia of pregnancy ◆ Acute intermittant porphyria ◆ Essential Hypertension ( 90% of all cases of hypertension） Essential Hypertension Essential hypertension occurs in patients who have arterial hypertension without a clear, definable cause. Also referred to Primary or idiopathic