吸虫概论、华支睾吸虫.ppt

吸 虫  trematode 消化系统: 口、咽、食管和肠管 Indirect life cycle Need 1~2 intermediate hosts 世代交替 基本过程： Clinically important trematodes: 大小: 10-25 × 3-5mm 形状: 葵瓜子状 内部结构: 雌雄同体 * * Trematode 吸虫概论 Clonorchis sinensis 华支睾吸虫 Class Trematoda (吸虫纲) Digenetic trematode (复殖吸虫) 叶状或舌状 背腹扁平 两侧对称 口吸盘 ; 腹吸盘 无体腔 morphology Adult: 生殖系统: 除血吸虫外，均为♀♂同体 morphology Life cycle 基本阶段: Adult Egg Miracidium Sporocyst Redia Cercaria Encysted metacercaria Miracidium(毛蚴) Sporocyst(胞蚴) Redia(雷蚴) Cercaria(尾蚴) Encysted metacercaria(囊蚴) 华支睾吸虫 Clonorchis sinensis 肝吸虫 (liver fluke) 成虫寄生在人体肝胆管内 引起华支睾吸虫病 Morphology Life cycle Diagnosis Epidemiology Contents: Prevention Pathogenicity Morphology﹡ living adult dead adult Adult: Morphology﹡ 口吸盘 腹吸盘 子宫 (eggs) 肠 卵黄腺 卵巢 受精囊 睾丸 Adult: Size: Shape: 芝麻/灯泡 Color: 黄褐色 Shell: 厚 Content: 毛蚴 Egg: Morphology﹡ Life Cycle Adults live in the host’s hepatic bile duct（肝胆管）. Eggs are passed with feces（粪便） into water. Eggs are ingested by the first intermediate host(淡水螺), miracidium hatches. Cercaria exit from snail（淡水螺）. Cercaria penetrate the skin of a fish , “encyst” in fish muscle as metacercariae（囊蚴）. Human are infected by eating raw and undercooked fish. Metacercariae “excyst”in small intestine and larva（幼虫） migrates into bile ducts of the liver. Larva mature and produce eggs in bile ducts. 1st : snail（淡水螺） ; 2nd: fresh water fish and shrimp Brief summary of life Cycle Infective stage: encysted metacercaria; Infective mode and route: eating raw or undercooked fresh water fish and shrimps(虾) with metacercaria; Site of inhabitation: hepatic bile ducts（肝胆管）; Intermediate host: Brief summary of life Cycle Final host: human /cat, dog ; Reservoir host: cat, dog ; Life span: 20-30 years ; 危害部位：次级胆管 致病因素：虫体的机械刺激及其代谢产物 病理变化：胆管炎、胆囊炎、阻塞性黄疸、胆结石、诱发肝癌 Pathogenicity 致病机理： Pathogenicity 临床表现： 消化系统症状为主 轻度感染：上腹不适