心脏瓣膜病 (65p)案例实例.pptVIP

Pathophysiology LV overloading Increased diastolic wall-tension produces eccentric hypertrophy (increase both in chamber size and wall thickness) Reduced diastolic compliance (Acute AI) Very high diastolic compliance (Chronic AI) Eccentric Hypertrophy Pathophysiology Baseline myocardial oxygen demand higher than normal because of increased LV mass Reduced coronary perfusion pressure Lower diastolic pressure Increased LVEDP Pathophysiology Myocardial contractility is usually preserved until late in course of the disease Late in disease there is progression to irreversible contractile imp