多层微流道结构于微液滴定量与操控的应用-citeseerx.pdfVIP

多層微流道結構於微液滴定量與操控的應用 On-Demand Liquid-in-Liquid Droplet Metering and Fusion Utilizing Pneumatically-Actuated Membrane-Type Valves 利用薄膜快速的上下運動可將連續的水流在油流輔助下切割成微小 的水滴，本研究以電腦整合眾多薄膜的運動，再配合輔助流道的設 計，產生液滴定量與融合的效果，可依實際需求快速產生定量且具 特定組成的液滴，並在後端整合薄膜開關以產生移動路徑切換的效 果，將產生的液滴依實際需求導引至目的地。 IOP PUBLISHING JOURNAL OF MICROMECHANICS AND MICROENGINEERING J. Micromech. Microeng. 18 (2008) 115005 (10pp) doi:10.1088/0960-1317/18/11/115005 On-demand liquid-in-liquid droplet metering and fusion utilizing pneumatically actuated membrane valves Bo-Chih Lin and Yu-Chuan Su Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan E-mail: ycsu@ess.nthu.edu.tw Received 5 March 2008, in final form 28 August 2008 Published 23 September 2008 Online at stacks.iop.org/JMM/18/115005 Abstract This paper presents an active emulsification scheme that is capable of producing micro-droplets with desired volumes and compositions on demand. Devices with pneumatically actuated membranes constructed on top of specially designed microfluidic channels are utilized to meter and fuse liquid-in-liquid droplets. By steadily pressurizing a fluid and intermittently blocking its flow, droplets with desired volumes are dispersed into another fluid. Furthermore, droplets from multiple sources are fused together to produce combined droplets with desired compositions. In the prototype demonstration, a three-layer PDMS molding and irreversible bonding process was employed to fabricate the proposed microfluidic devices. For a dispersed-phase flow that is normally blocked by a membrane valve, the relationship between the volume (V) of a metered droplet and the corresponding valve open time (T) is found to be approximately V = kTa, in which k and a are constants determined mainly by the fluid-driving pre