curb challenges of the trojan horse approach smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery文档精品.pdfVIP

NIH Public Access Author Manuscript Adv Drug Deliv Rev . Author manuscript; available in PMC 2014 October 15. N Published in final edited form as: I H Adv Drug Deliv Rev . 2013 October 15; 65(10): 1299–1315. doi:10.1016/j.addr.2012.11.007. - P A A u Curb Challenges of the “Trojan Horse” Approach: Smart t h o Strategies in Achieving Effective yet Safe Cell-penetrating r M a Peptide-based Drug Delivery n u s 1,2,* 1 1 2 3 c Yongzhuo Huang , Yifan Jiang , Huiyuan Wang , Jianxin Wang , Meong Cheol Shin , r i 4 5 5 3,4,5,* p Youngro Byun , Huining He , Yanqin Liang , and Victor C. Yang t 1Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Hai-ke Rd, Shanghai 201203, China 2School of Pharmacy, Fudan University Key Lab of Smart Drug Delivery, MOE/PLA, Shanghai 201203, China 3University of Michigan College of Pharmacy 428 Church Street, Ann Arbor, MI 48109-1065, USA N I 4 H Department of Molecular Medicine and Biopharmaceutics Seoul National University Seoul, - Korea P A 5 Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and A u Diagnosis, School of Pharmacy, Tianjin Medical University Tianjin 300070, China t h o r Abstract M a Cell-penetrating peptide (CPP)-mediated intracellular drug delivery system, often specifically n u termed as “the Troja