鼻腔鼻窦腺样囊性癌18例临床分析.doc

鼻腔鼻窦恶性纤维组织细胞瘤11例临床分析 向银洲1，余林2，魏莲枝2 （1.三峡大学人民医院,湖北 宜昌 443000;2.重庆医科大学附属第一医院耳鼻咽喉科 重庆 400016） [摘要] 目的：探讨鼻腔鼻窦恶性纤维组织细胞瘤的临床特点。方法：对1990年1月至2010年1月收治的11例原发于鼻腔、鼻窦的恶性纤维组织细胞瘤的临床表现、诊断、治疗方法和随访结果进行分析。结果：鼻腔鼻窦恶性纤维组织细胞瘤临床症状多样化，诊断主要依靠病理，治疗采用根治性手术结合放疗，11例患者中随访10例，失访1例，3年生存率为45.5％(5／11)，5年生存率为36.4 ％(4／11)。结论：鼻腔鼻窦恶性纤维组织细胞瘤临床症状不典型，恶性程度高，易复发，预后有赖于病理分型和临床分期，早期诊断、根治性手术加术后放疗是提高本病生存率的关键。 [关键词] 恶性纤维组织细胞瘤；鼻肿瘤；鼻窦肿瘤 [中图分类号] R733．4 [文献标识码] A [文章编号] Clinical analysis on 11 cases of malignant fibrous histiocytoma of nasal cavity and sinuses XIANG Yin-zhou1, YU Lin2, WEI Lian-zhi2 (1Department of Otolaryngology，eoples Hospital of Three Gorges University, Yichang,443000,China;2 Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University ) Corresponding author: XIANG Yinzhou(Email:2402342279@) 作者简介:向银洲(1971-), 男,副主任医师,医学硕士.主要研究方向为头颈肿瘤基础与临床Email:2402342279@.Tel Abstract Objective：To explore the clinical characteristics and treatment effect of of nasal cavity and sinuses．Methods：1 patients with malignant fibrous histiocytoma in nasal cavity and paranasal sinus were analyzed retrospectively in our department from 1990 to 2010, including clinical presentation, diagnosis, treatment and follow-up data. Results： of nasal cavity and sinuses were distinct clinicopathological category. Diagnosis depended on pathology. Radical operation and radiotherapy were put into use to treat it. 10 patients were followed up and 1 case was lost to visit. The survival rates of 3 and 5 years were 45.5％(/11)and 36.4％(/11) respectively．Conclusion：he clinical symptoms of malignant fibrous histiocytoma of nasal cavity and sinuses were noncharacteristic. MFH had an aggressive behavior and easy recurrence．The prognosis related to pathological category and clinical stage. Early diagnosis，radical operation and postoperative radiotherapy were key steps to apply to improve the survival rate . Key words: malignant fibrous histiocytoma；Nose ；Paranasal sinus malignant fib