Ubiquitin C gene Structure, function, and transcriptional regulation推荐.pdf

Advances in Bioscience and Biotechnology, 2013, 4, 1057-1062 ABB /10.4236/abb.2013.412141 Published Online December 2013 (/journal/abb/) Ubiquitin C gene: Structure, function, and transcriptional regulation * Lucia Radici , Marzia Bianchi, Rita Crinelli, Mauro Magnani Department of Biomolecular Sciences, Biochemistry and Molecular Biology Section, University of Urbino “Carlo Bo”, Urbino, Italy * Email: radici.lucia@, marzia.bianchi@uniurb.it Received 10 October 2013; revised 12 November 2013; accepted 27 November 2013 Copyright © 2013 Lucia Radici et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT of ubiquitination of a target protein range from the well-known protein degradation through the 26S protea- Ubiquitin C (UbC) is one of the four genes encoding some, to protein trafficking, cell-cycle regulation, DNA for ubiquitin in the mammalian genome. It has been repair, apoptosis and signal transduction [1-6]. Ubiquitin described as the most responsive gene to cellular is one of the most abundant protein in eukaryotic cells, treats such as UV irradiation, heat shock, oxidative constituting 0.1% - 5% of total proteins but, despite its stress and translational impairment; it