脉搏波速与冠状动脉炎症状态的关系研究.docVIP

脉搏波速与冠状动脉炎症状态的关系研究 ? l840? 脉搏波速与冠状动脉炎症状态的关系研究 龚武田,李家富,罗廷福 PJCCPVDNovember2011.Vo1.19No.11 【摘要】目的检测冠心病患者脉搏波速(PulseWaveVelocity,)及血清炎症因子高敏c反应蛋白(Hs — CRP),白介素一6(IL一6),肿瘤坏死因子一0【(TNF一0【),探讨PwV与冠状动脉炎症状态的相互关系.方法采 用对照,单盲,条件分组,非随机的方法.以2009年3月一2010年3月我院心内科住院冠心病(CHD)患者140例为 研究对象,检测PwV,抽清晨血查Hs—CRP,IL一6,TNF一0【.结果PwV正常与异常组Hs—CRP,IL一6,TNF— 比较,差异均有统计学意义(Plt;0.05).PwV正常组的Hs—CRP为(1.37±0.77)mg/L,异常组的Hs—CRP 为(5.97±5.39)mg/L,Hs—CRP与PWV呈正相关,直线回归和相关分析(r=0.573,Plt;0.01);PwV正常组的IL 一 6为(49.1±30.1)ng/L,PWV异常组的IL一6为(77.2±55.5)ng/L,IL一6与PwV呈正相关,直线回归和相关 分析(r=0.387,Plt;0.01);PWV正常组的TNF—or.为(1063±343)ng/L,PwV异常组的TNF一0【为(1517±668) ng/L,TNF—ft.与PwV呈正相关(r=0.327Plt;0.01).结论PwV与炎症因子关系密切,二者呈正相关关系,可互 相反映.当PwV大于正常时,炎症因子浓度增高,当Hs—CRP接近6.0m#L,IL一6gt;80ng/L,TNF一仅gt;1500ng/L 时,PwV增加,提示动脉僵硬度增高. 【关键词】脉搏波速;高敏c反应蛋白;白细胞介素一6;肿瘤坏死因子一0【 【中图分类号】R541.4R543【文献标示码】A【文章编号】1008—5971(2011)l1—1840—03 TheRelationshipbetweenPulseWaveVelocity(PWV)andCoronaryArteryInflammationGONGWu—tian,LIJia一 {uLUOTing—fu.DepartmentofCardiology,WenfiangPeoplesHospitalofChengduCity.Chengdu611130.China 【Abstract】ObjectiveToinvestigatetherelationshipbetweenPwVandcoronaryarteryinflammationsuchashighsen- sitivityCreactiveprotein(Hs—CRP),interleukin一6(IL一6),tumornecrosisfactor—(TNF—o【)inpatientswithcoronary heartdisease.MethodsThestudyisinthewayofcontrol,single—blind,conditionsmatchthegroupandnon—random.140 patientswithcoronaryarterydiseasewereintheDepartmentofCardiology,MyHospitalfrom2009,3to2010.Thesecasesin— cludedmale72andfemale68withtheage40～85years.Excludingsuhjeets:patientswithmainarteryinflammation,rheumato— logicaldisease,Infection,cancer,renalinsufficiency,hyperthyr0idism,liverfailureandsoon.Thepatientsweremeasured PwV,serumhighsensitivityCreactiveprotein(Hs—CRP),interleukin一6(IL一6),tumornecrosisfactor—(T_NF—). ResultsComparingHs—CRP,IL一6,TNF—o~betweennormalPWVandabnormalPWVgroup.Hs—CRP,IL一6,TNF— c~betweennormalPwVandabnormalPWVgroupweresignificantlydifferent(Plt;0.05).Hs—CRPinnormalPWVgroupwas (1.37±0.77)mg/L,Hs—CRPinabnormalPwVgroupwas(5.