钒化合物抗糖尿病作用的研究进展swc!.pdfVIP

第 2 1 卷 第 5 期 化 　学 　进 　展 Vol . 2 1 No . 5 2009 年 5 月 PROGRESS IN CHEMISTRY 　May , 2009 钒化合物抗糖尿病作用的研究进展 韦 　丹 　丁文军 　周 　桔 　彭 　端 　李 　明 ( 中国科学院研究生院生命科学学院环境与健康研究室 　北京 100049) 摘 　要 　在糖尿病的治疗研究中 ,体内和体外的研究表明 ,钒化合物可以降低 Ⅰ型和 Ⅱ型糖尿病血糖 , 促进葡萄糖转运和糖原合成 ,具有“类胰岛素作用”。本文综述了近年来钒化合物在降低和改善糖尿病症状 的生物效应及其通过胰岛素信号通路在降糖作用的分子机制的研究进展 。 关键词 　钒化合物 　糖尿病 　抗糖尿病作用 + ( ) 中图分类号 : O61451 1 ; R1512 ; R9143 　文献标识码 : A 　文章编号 : 1005281X 2009 Research Progress in AntiDiabetic Effects of Vanadium Compounds Wei Dan 　Ding Wenj un 　Zhou J u 　Peng Duan 　L i Ming (Laboratory of Environment and Health , College of Life Sciences , Graduate University of Chinese Academy of Sciences , Beij ing 100049 , China) Abstract 　It is well known that diabetes mellitus (DM) is a chronic disease caused by inherited andor acquired deficiency in production of insulin by the pancreas , or by the ineffectiveness of the insulin produced . Numerous studies have shown that vanadium and its compounds improve glucose homeostasis and insulin resistance in Type Ⅰand Type Ⅱ diabetes mellitus. Vanadium and its compounds appear to have a profound impact on insulin action through the insulin signaling cascade , but the underlying mechanism is not fully understood . This review summarizes recent work to identify the effects of pharmaceutical treatment of vanadium compounds on insulin signaling and glucose uptake , in an attempt to characterize the molecular mechanism ac