Neuronal Migration神经元的迁移.ppt

Neuronal Migration in CNS Development After neurons are born, they migrate to their final destinations:Radial migrationTangential migration Radial migration along radial glia cells in the developing CNS: Serial section electron microscopy: Migrating neurons in the intermediate zone are intimately apposed to radial glial fibers (striped vertical shafts, RF1-6), which extend short lamellate expansions (LE) at a right angle to their main axis. Nuclei (N) of migrating neurons are elongated, and their leading processes (LP) are thicker and richer in organelles than their trailing processes (TP). Each leading process extends several pseudopodial endings (PS). Several cross sections through a migrating neuron are shown (a–d); migrating cell partially encircles the shaft of the radial glial fiber and these intimate contacts are continuous throughout the length of the cell. OR, optic radiation, From Sidman and Rakic (1973). Radial migration along radial glia in the developing Cerebellum, Hippocampus and Cortex In vitro migration of hippocampal neurons along the process of astroglia cells from the cerebellum. Neurons can migrate along a variety of radial glia fibers. Migrating neurons are apposed to glia Cells, which guide them from the ventri- cular zone to their final destination. Cortical neurons are migrating over long distances Diagram of various trajectories taken by migrating cortical cells co-generated at the same embryonic day, but destined to settle in various areas of the cortical plate. Some cells generated in the neocortical neuroepithelium migrate in the lateral cortical stream for four or more days before reaching their target destination. The role of the Reelin protein in cortical development. A) Reelin is expressed by Cajal Retzius cells in the outer layer of the developing cortex. As neurons migrate out along the glial fibers, Reelin is proposed to organize the cortical plate. B) Reelin binds to a receptor, VLDLR or ApoER2 in the surface membrane,