口腔粘膜精品教学（中山大学）3.斑纹类疾病.pptVIP

Oral Leukoplakia(OLK) Common diseases,prevalence rate only next to RAU, about0.51％. Mostly appears in young adults, female more than male; skin and mucosa can onset at the same time or separately long term erosion tend to canceration, WHO classify it into precancerous condition. Psychological factors Endocrine factors Immune factors：Immune reactivity disease mediated by Tcells. Infection factors Microcirculation disturbance Genetic factor Basic lesion：white or graywhite linear figure formed by little papules Bilaterally symmetrical , can occur at any parts of oral mucosa, mostly in buccal mucosa Subjective symptom：local sensitive and burning pain, be aware of rough mucosa. Oral lesion：clinical classification according to forms：reticulated、plaque、 papule、shrink according to conditions ：Hyperaemia erosion type、nonerosion type Skin lesion aubergine or kermesinus polygon flat papule； Wickham lines：Small white spots or the reticular white stripes can be seen in papule. clearly seen under magnifying glass when applying the paraffin wax in the surface of papule. Epithelium parakeratosis Liquefaction degeneration of basal cells Infiltration of lymphocyte cells adjacent to basement membrane is the typical feature. Clinical features：mostly seen in middle-aged women, symmetrical lesion,the typical lesion formed by white papule can present hyperaemia, erosion or even ulceration Tissue biopsy if necessary. psychotherapy and systemic therapy local therapy systemic therapy： immunosuppressor and immunomodulator Leukokeratosis Definition White benign hyper-keratinized lesions of the oral mucosa with apparent causes. Appears as a flat, single white patch with exact stimulating factor. white lesion fade away when 1-2weeks after removing the stimulation. Oral Leukoplakia oral leukoplakia-definition A predominantly white patch or plaque of the oral mucosa that can not be characterized clinically or pathologically as any other definable lesion.