肠灵3号对气滞血瘀型溃疡性结肠炎的临床研究-中医内科学专业论文 word格式.docxVIP

副作用等优点。是治疗气滞血瘀型溃疡性结肠炎的安全有效方药，其机理可能与以下几方面有关:1.调节机体免疫功能2.抗氧自由基损伤3.促进溃疡面愈合4.调整菌群失调5.改善肠粘膜的血液循环6.改善全身症状。关键词：肠灵3号；气滞血瘀；溃疡性结肠炎；临床研究ClinicalResearchintheblood stasisduetoqistagnationof UlcerativeColitisTreamentbyChangling3AbstractObjective:Toobservetheclinicalcurativeeffectoftreatingulcerativecolitis(UC)withChangLing-3 andexplore themechanismofulcerative colitiswithtreatmentChangLing-3fromtheoreticalandclinicalaspects.Method:80caseswithUCweredividedintotwogroupsatrandom.ChangLing-3wasgiventreatmentgroup,granulawhichwasblendedbywarmingboiledwaterto150mlandthecontrolgroupwascoloclysteredwithDioctahedralsmectite(3g)blendedintophysiologicsaline(100ml)withthesameessentialtreatment.Results:Thetotallyeffectiverateoftreatmentgroupcometo95.0%,whilethatofcontrolgroupwas72.5%,andtherewasasignificantdifferencebetweenthetreatmentgroupandcontrolgroup(P0.05).Treatment groupcanimprove significantlythesymptomssuchasdiarrhea, tenesmus, thescorchofanus，bellyache, abdominaldistension,andthecurativeeffectisbetterthanthatofcontrolgroup.Eachgroupwastreatedonehoureachtimeandonetimeaday.Atreatmentcoursewas15days.Theclinicaleffectwasevaluatedbytherapeuticeffectcriterion,thechangeofmainsymptomsandpathologicalchangesofmucosaaftertwotreatmentcourses.Conclusions:ChangLing-3isasafeandeffective medicineoftreatingUC,andthe mechanism mightberelatedtoregulatieimmunologicfunction, anti－oxygen free radicle injury, accelerate ulcerative recovery,adjustmentalterationofintestinalflora，improvebloodcirculationofintestinalcanalandsystematicsymptoms.Keywords：ChangLing3;bloodstasisduetoqistagnation;Ulcerativecolitis;Clinicalobservation引言溃疡性结肠炎(ulcerativecolitisUC)，又称非特异性溃疡性结肠炎，是一种原因不明的慢性直肠和结肠炎性疾病。病变主要位于结肠的粘膜层，以溃疡为主，多累及直肠和远端结肠，也可遍及整个结肠。临床上以腹痛腹泻，粘液血便及里急后重为主要表现，病程迁延不愈长达十几年甚至几十年,有发生癌变的可能性。尽管西医对本病的认识有将近百年历史，现代研究也已经进入了分子、细胞因子阶段，但其病因、病机尚未完全清楚。目前认为与免疫异常、感染因素、氧自由基损伤、饮食因素、精神因素乃至遗传等多种因素有关。西药以柳氮磺胺毗啶(SASP)及其衍生物和糖皮质激素等免疫抑制剂为主，辅以抗炎、止血、止泻等治疗，但这些方法只能暂时控制病情，疗效不确切、副作用多且容易复发。中医药在治疗本病具有整体与局部、辨证与辨病、的标本兼顾特点，并且用药安全，毒副作用少，经济低廉，突出中医特色，