淋巴造血系统疾病（英）.pptVIP

Classification According to WHO Myeloproliferative neoplasm (MPN,骨髓增生性肿瘤) Medullary system and Lymph tumor with Eosinophilic cell histiocytosis(髓系和淋巴肿瘤伴嗜酸性细胞增多症) Myelodysplastic/ MPN (骨髓异常增生/骨髓增生性肿瘤) Myelodysplastic syndrome（MDS,骨髓异常增生综合症） acute myeloid leukaemia（AML） and related precursor neoplasm（急性髓性白血病及其相关前体细胞肿瘤） MYELOID NEOPLASM Type origin, differentiated degree, patients condition acute Acute lymphoblasric leukemia (ALL ,急性淋巴母细胞白血病) Acute myelogenous leukemia (AML,急性粒细胞/髓细胞白血病) chronic Chronic lymphocytic leukemia ( CLL,慢性淋巴细胞白血病) Chronic myelogenous leukemia ( CML,慢性粒细胞/髓细胞白血病) Classification According to the type of Leukemic cell Myelogenous leukemia (髓细胞性白血病) Lymphoblasric leukemia(淋巴母细胞性白血病) Monocytic leukemia（单核细胞性白血病） Megakaryocytic leukemia（巨核细胞性白血病） Erythrocytic leukemia（红细胞性白血病） Basic pathological changes Marrow: leucoblast hyperplasia , hematogenesis Peripheral blood: total white cell count (TWBC) juvenile cell(幼稚细胞) thrombocytopenia(血小板减少) Lymphonode: swell, juvenile cell(幼稚细胞) Spleen : swell, oncocyte infiltrating, oppression white pulp Liver：swell, oncocyte infiltrating in sinus hepaticus and portal area Acute myeloid leukemia ( AML) AML are tumors marked by a blockage in the differentiation of early myeloid cells. Immature myeloid cells accumulate in the marrow, replacing normal elements, and frequently circulate in the peripheral blood. AML- clinical manifestations Anemia Hemorrhage Bone pain Fatigue Fever Hepatosplenomegaly Lymphadenopathy AML - Diagnosis Laboratory findings: Peripheral blood increased number of white cells immature white cells BM aspiration immature white cells Peripheral blood Bone marrow biopsy Concentration of immature cells( in other organs out Bone marrow) tumorous mass--myeloid sarcoma(髓肉瘤) 96% --granulocytic sarcoma(