Cells-of-the-Immune-System(细胞的免疫系统).pptVIP

The Cells of the Immune System Charlie McSharry Aims and Objectives By the end of the lectures and lab you should be able to: appreciate the origin of the cells of the immune system from the bone marrow describe in simple terms the microscopic appearance of the cells of the immune system: B and T lymphocytes plasma cells macrophages dendritic cells describe in simple terms other effector cells such as: neutrophil, eosinophil and mast cells [polymorphs] platelets stromal cells erythrocytes and platelets Platelets and clotting Granulocytes or Polymorphonuclear (PMN) Leukocytes A group of white blood cells is collectively referred to as granulocytes or polymorphonuclear leukocytes (PMNs). Granulocytes are composed of three cell types identified as neutrophils, eosinophils and basophils, based on their staining characteristics with certain dyes. These cells are predominantly important in the removal of bacteria and parasites from the body. They engulf these foreign bodies and degrade them using their powerful enzymes. neutrophil Polymorphonuclear leucocyte - NEUTROPHIL multi-lobed nucleus. 50-70% of circulating WBC (higher numbers suggestive of bacterial infection). The fine granules stain poorly with acidic and basic dyes neutrophil. Primary granules electron dense - contain bactericidal enzymes Lysozyme, myeloperoxidase; neutral proteases (i.e. elastase); and acid hydrolases (B-glucoronidase Secondary granules – smaller, not electron dense. lysozyme, collagenase and lactoferrin and cathepsin B). Phagocytosis and killing of ingested microorganisms. The phagosome fuses with granules to destroy internalized bacteria, oxygen dependent respiratory burst. DO NOT function as APCs. Neutrophils are the 1st cells to arrive. A number of substances produced during an inflammatory response recruit neutrophils to a site of inflammation. lymphocyte LYMPHOCYTES responsible for the specific immune response. Represent 20-40% of circulating WBC in blood extr