january27-国立水俣病总合研究センター.pdf

NIMD FORUM 2011 abstract Methylmercury Toxicity: Up-to-date Research on Mechanisms, Toxicology and Pathology January 27-28, 2011 Venue: Minamata Disease Archives, Conference Hall 55-10 Myojin, Minamata City, Kumamoto 867-0055, Japan National Institute for Minamata Disease http://www. nimd.go.jp January 27 9:20-9:25 Opening address Koji Okamoto (NIMD, Japan) 9:25-9:35 Brief introduction Fusako Usuki (NIMD, Japan) 9:35-10:55 Session 1 Chair: Akira Yasutake (NIMD, Japan) William Rostene (Inserm, France) 1-1. Chris Newland (Auburn University, USA) Neuroprotection and Methylmercury: Selenium, DHA, and Nimodipine (魚由来成分のセレンやDHA およびカルシウム遮断薬である ニモジピンのメチル水銀毒性防御効果) Follow-up remark: Mineshi Sakamoto (NIMD, Japan) Protective effects of selenomethionine against methylmercury-induced neuronal degeneration in developing rat brain (メチル水銀により惹起 されるラット発達期脳の神経変性に対するセレノメチオニンの抑制効果) 1-2. Sandra Ceccatelli (Karolinska Institute, Sweden) Effects of methylmercury on survival and differentiation of neural stem cells (神経幹細胞の生存と分化に及ぼすメチル水銀の影響) 10:55-11:15 Coffee break 11:15-12:25 Session 2 Chair: Masaaki Nakamura (NIMD, Japan) Michael Aschner (Vanderbilt University Medical Center, USA) 2-1. Takashi Toyama (Tsukuba University, Japan) Keap1/Nrf2 system regulates cellular accumulation of methylmercury, thereby blocking its toxicity (メチル水銀蓄積に対するKeap1/Nrf2 シス テムの制御) 2-2. Yoshito Kumagai (Tsukuba University, Japan) A unique protein mediating cell