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Special Topics in Genetics 路光予博士 東吳大學微生物學系碩士班 授課目標 2006年Nobel Prize的生物醫學獎項頒給了發現interference RNA的兩位學者。 2006年Nature上發表了一篇在老鼠中發現經由RNA 可以造成一種非孟德爾遺傳形式的表形改變的研究報告。 這篇報告被選為2006生物研究年度重大發現之一。 這些研究與1982年以降的研究發現的RNA不僅是一種遺傳訊息的攜帶者也是一種具酵素活性的生物分子的事實都再再的指出，RNA分子不再是單純的一種介於DNA與蛋白質分子間的遺傳訊息的中介者，而是在生物的基因表現上與生物功能上扮演著獨特的地位。 本學期的授課目標就是針對過去二十幾年來科學家對RNA的研究進行研讀，以期對RNA分子的生物功能能有更進一步的瞭解。 授課時間及授課內容 授課時間 授課內容 2.27-3.06 Introduction 3.08-4.10 (7X) RNAs can work as an enzyme Self-splicing RNA L-19 IVS Ribozyme Peptidyl transferase RNA world---ribocyte 4.17-6.14 (14X) Interference RNA and its application 6.26-6.28 (2X) RNA-mediated epigenetic change 成績考評：書面報告佔50%，上課討論及口頭報告佔50%。 Questions in Genetics and a Brief Reviewof Genetic Research  The Science of Genetics is concerned with four specific puzzles about organisms They are: 1st Puzzle : Resemblance between parents and their offsprings Humans give birth to humans Dogs give birth to dogs How is this clear species identities passed from parents to their immediate offspring? 2nd Puzzle : How can a single egg give rise during development to an enormously complex adult organism with anatomical and physiological features that are characteristics of its parental species? How does a single cell produce the immense diversity of cell types that make up a whole organism, arranged in tissues and organs that are like those of the parents that produced the cell? 3rd Puzzle : A child may have her mother’s eye color or a nose resembling her father’s, and she may grow taller than either parent What are the causes of these partial similarities to one p