儿童造血系统和贫血简介 Introduction of Hematopoietic System and Anemia in Children.pptVIP

2 months girl，Hb100g/L，normal？ one year old boy，WBC10×109/L，N60%，L40%，normal？ 1 hour new born，vomiting blood，is blood from mother or from itself？ Hematopoiesis ： Hematopoiesis in fetus Hematopoiesis after birth Blood features： RBC and Hb WBC BPC Blood volume Hematopoiesis in fetus Developmental hematopoiesis occurs in three anatomic stages: mesoblastic（yolk sac） hepatic（liver） myeloid（marrow） Hematopoiesis in fetus Hematopoiesis after birth Active hematopoietic tissue (red marrow) Fatty tissue (yellow marrow) myeloid hematopoiesis Infant: all bone was full of red marrow, no yellow marrow, no hematopoiesis store young children: more red marrow, less yellow marrow, a little hematopoiesis store Older children and adult: less red marrow, more yellow marrow, more hematopoiesis store in infant, Liver, splen may be a hematopoiesis organ in response to certain severe hematologic stresses (hemolytic anemia, infection, etc), just like the fetus. Blood features RBC and Hb Hb ：from high→low→ normal RBC： from high→low→ normal physiological anemia cause：RBC production↓，RBC destruction↑，blood dilution time：2~3 month In term infant : Hb100g/L in preterm infant: Hb 70~90g/L 1.WBC： from high to low to nomal（at 8 years old） (10×109/L in infancy) 2.The change of WBC?in children BPC：150×109~250×109/L At birth： HbF 70% HbA 30% HbA2 ＜1% 1 yr ： HbF＜5% HbA 95% HbA2 2%~3% More than 2 yr ： HbF＜2% HbA 95% HbA2 2%~3% blood volume Newborn： 10% bodyweight Children：8%~10% bodyweight Adult：6%~8% bodyweight 2 months girl，Hb100g/L，normal？ one year old boy，WBC10×109/L，N60%，L40%，normal？ 1 hour new born，vomiting blood，is blood from mother or from itself？ Anemia in children What is anemia： Hb/RBC is lower than normal ＜6 month： new born：Hb145g/L 2～6 month :Hb100g/L 6month～6y： Hb110g/L 6y～14y： Hb120g/L 1.Classification from cause of anemia Hypoproduction disorder