天冬氨酸-丝氨酸-丝氨酸重复多肽促进毛发生长作用及其机制研究-皮肤病与性病学专业论文.docx

第三军医大学博士学位论文英文缩写一览表英文缩写英文全称中文全称8DS SOctuplet repeats of天冬氨酸．丝氨酸．丝氨酸重复aspartate．serine．serine peptides多肽ddH20deionized distilled water去离予蒸馏水DEPCdiethyl pyrocarbonate二乙基焦碳酸盐 DMEMDulbecco’S modified Eagle’SDMEM培养基mediumDMSOdimethyl sulfoxide二甲基亚砜DNAdeoxyribonucleic acid脱氧核糖核酸DPdermal papilla毛乳头 mPCShuman dermal papilla cells人毛乳头细胞 Epeppendorf微量离心管hhour小时IRSinter root sheath内毛根鞘LEFleukokinsis-enhancing factor淋巴细胞增强因子mlnminute分钟mRNAmessenger ribonucleic acid信使核糖核酸PBSphoshpate buffered saline salution磷酸盐缓冲液RT．PCRreal time polymerase chain reaction实时定量聚合酶链式反应rpmrotation per minute姨|贪RNAribonucleic acid核糖核酸RNaseribonuclease核糖核酸酶RTreverse transcription逆转录万方数据第三军医大学博士学位论文Effect of 8DSS on Hair Growth and Its PossibleMechanismsAbstractBackground：Hair play a role in protecting，promoting social interaction and maintaining beautiful．Hair follicle is a complex structure of the skin appendages which undergoes a cycle of growth(anagen phase)，regression(catagen phase)and resting(telogen phase)．When the hair follicle cycle is in disorder，hair loss will occurred．In China，alopecia areata and androgenic alopecia are the most common type of hair loss．With thesocial pressure，environmental problems increasingly become prominent for the people，the incidence of hair loss increased year by year，and the trend was younger．Hair loss not only affects the appearance and mental on patients and their families，but also resulting in decreased quality of life and communication problems for patients．However,the therapeutic effect of hair loss are still very scarce．Currently，the only FDA-approved oral medication finasteride and externally applied agent minoxidil have definite effect．The use of these agents is associated with adverse effects，including dryness，itchiness，and loss of libido or erectile dysfunction．Therefore，to promote hair follicle regeneration，new drugs research which can promote hair regrowth is becoming increasingly important．Hair follicles，composed of multiple layers of epithelial and mes