网络结构驱动的生物标记筛选及疾病预测模型研究-流行病与卫生统计学专业论文.docx

山东大学博士学位论文3．2．3统计模拟623．2．4实例验证643．3结果643．3．1模拟结果643-3．2实例结果703．4讨论．72第四章网络结构驱动的疾病风险预测模型754．1背景754．2方法．774．2．1原因别风险模型774．2．2基于贝叶斯网络估计相对风险784．2．3统计模拟804．2．4实例验证834．3结果864．3．1模拟结果864．3．2实例结果894．4讨论98第五章结论一1 025．1创新之处．1035．2不足之处．104参考文献105致谢1 1 3攻读学位期问发表的学术论文114学位论文评阅及答辩情况表1 1 5附英文发表文章1 17万方数据山东大学博士学位论文CONTENTCHINESE ABSTRACT。1ABSTRACT．1lDENOTATION．．23CHAPTER 1 INTRODUCTION251．1 BIOMARKER SELECTION．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．271．2 DISEASE SCREENING．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．301．3 DISEASE RISK PREDICTION． ．．．． ．．． ．．321．4 OUTLINE OF THE DISSERTATION．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．． ．．．．．．．34CHAPTER 2 GENE NETWORK STRUCTURE．DRIVEN BAYESIANBIoMARKER SELECTION MODEL。35：!．1 BACKGROUND．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．35 2．2 METHODS．．．．．．．． ．． ．．372．2．1 ND．BVS model．372．2．2 Posterior distributions derivation．39：!．2．3 Simulation studies． ．． ．．．．．．43 2．2．4 Application．．442．3 RESULTS．．452．3．1 Simulation results．452．3．2 Application results．．482．4 DISCUSSION ．． ．．． ．． ． ．． ．．．． ．．．．．．54CHAPTER 3 NETWORK STRUCTURE-DIUVEN MODEL FOR DISEASE SCREENING。573．1 BACKGROUND．．．．．．．．． ． ．573．2 METHODS．．．．．．．． ．583．2．1 Bayesian network．58：；．2．2 Neural network．．．．．．． ．60万方数据山东大学博士学位论文3．2．3 Simulation studies623．2．4 Application～643．3 RESULTS．．643．3．1 Simulation results．643．3．2 Application results一703．4 DISCUSSION．．．． ．．． ． ．．．．．．．．．。．．72CHAPTER 4 NETWoRK STRUCTURE-DRlVEN MODEL FOR DISEASEIUSK PREDICTIoN．754．1 BACKGROUND．．75zI．2 METHODS774．2．1 Cause—specific hazard model．774．2．2 BN．based estimation ofrelative risks784．2．3 Simulation studies．． ．． ．． ．．． ．．．．．．．．．80 4．2．4 Application ．．． ．．．．． ．．．834．3 RESULTS．．864．3．1 Simulation results．864．3．2 Application results．．894．4 DISCUSSION．．． ．．． ．．．．．． ．． ．．． ．．．98 CHAPTER 5 CONCLUSIONS．1025．1 INNOVATIONS，1035．2 LIMITATIO