武大分子生物学课件chapter8f.pptVIP

Initiating replication in bacteria DnaA recruits the DNA helicase DnaB and the helicase loader DnaC DnaB interacts with primase to initiate RNA primer synthesis. Figure 8-27* Initiating replication in eukaryotes Eukaryotic chromosome are replicated exactly once per cell cycle, which is critical for these organisms Binding and unwinding Pre-replicative complex (pre-RC) formation and activation directs the initiation of replication in eukaryotes Initiation in eukaryotes requires two distinct steps: 1st step---Replicator selection: the process of identifying sequences for replication initiation (